Slacks Creek originally encompassed both sides of the Pacific Highway but in May 2002, the boundaries were altered so that the suburb was located only on the southern side of the highway. It is one of the oldest settled areas in the Logan district and was named after John Slack whose property was named Mungaree near the Logan River. He grazed cattle in the district from about 1845. John Slack died in 1861 and his son William remained in the area and leased land along the current Pacific Highway in between Paradise Road and the Loganlea Road Interchange.
When the first bridge over the Brisbane River was constructed in 1865, this land was opened up for closer settlement and the rough bush track through Mt Gravatt to the Logan River was known as Slack's Track. The main road to the south followed the current Pacific Highway to Loganlea Road and then crossed Slacks Creek to Waterford. Mail services began in 1878. The first store in Slacks Creek was opened by Sid Floate on the highway following WW2. It housed the telephone exchange, post office and general store. In march 1954, business became so brisk that Floate built a separate post office next door. Both of these building remain on the service road to the south of the Watland Street overpass, which was built in 1978. Another significant shopping centre in the area was the Argonaut Centre.
It evolved from Noel Burke's Golden Fleece service station on Kingston Road; the site was rebuilt in 1967 following a fire. An industrial estate was developed adjacent in 1968, and the Argonaut Centre was officially opened on 1st May 1969, and included a post office in 1970. The Moss Street industrial subdivision in the 1960's was the forerunner to today's extensive industrialization of the area.